rs3768955

What is the rs3768955 variant?

rs3768955 is a SNP (single nucleotide polymorphism) in the ITGAV (Integrin Subunit Alpha V (Vitronectin Receptor)) gene. It belongs to the Connective Tissue category and is part of the Coagulation & Microcirculation biological cluster. ITGAV encodes integrin alpha-V, which pairs with beta-3, beta-5, beta-6, or beta-8 to form receptors for fibronectin, vitronectin, and latent TGF-beta.

Biological role and pathway

This variant sits within the ITGAV gene, which is involved in the integrin-mediated cell adhesion / TGF-beta activation pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: ITGAV

rs3768955 is one of 1 known variant in the ITGAV gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs3768955

Research into ITGAV variants including rs3768955 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ITGAV and the rs3768955 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions