rs4654

What is the rs4654 variant?

rs4654 is a SNP (single nucleotide polymorphism) in the ITGB1 (Integrin Subunit Beta 1) gene. It belongs to the Connective Tissue category and is part of the Coagulation & Microcirculation biological cluster. ITGB1 encodes integrin beta-1, which pairs with multiple alpha subunits to form the major family of cell-matrix adhesion receptors.

Biological role and pathway

This variant sits within the ITGB1 gene, which is involved in the cell-ECM adhesion / integrin signaling pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: ITGB1

rs4654 is one of 1 known variant in the ITGB1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs4654

Research into ITGB1 variants including rs4654 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ITGB1 and the rs4654 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions