rs1887428

What is the rs1887428 variant?

rs1887428 is a SNP (single nucleotide polymorphism) in the JAK2 (Janus Kinase 2) gene. It belongs to the Jak Stat category and is part of the JAK-STAT Pathway biological cluster. JAK2 mediates signaling for erythropoietin, thrombopoietin, and many cytokine receptors including IFN-gamma receptor.

Biological role and pathway

This variant sits within the JAK2 gene, which is involved in the JAK-STAT cytokine signaling pathway. Genes within the JAK-STAT Pathway cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: JAK2

rs1887428 is one of 1 known variant in the JAK2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1887428

Research into JAK2 variants including rs1887428 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include JAK2 and the rs1887428 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions