rs1805123

What is the rs1805123 variant?

rs1805123 is a SNP (single nucleotide polymorphism) in the KCNH2 (Potassium Voltage-Gated Channel Subfamily H Member 2 (hERG)) gene. It belongs to the Cardiovascular category and is part of the Autonomic Nervous System biological cluster. KCNH2 encodes the hERG potassium channel essential for cardiac repolarization; mutations cause long QT syndrome type 2.

Biological role and pathway

This variant sits within the KCNH2 gene, which is involved in the cardiac repolarization / QT interval pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: KCNH2

rs1805123 is one of 2 known variants in the KCNH2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1805123

Research into KCNH2 variants including rs1805123 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KCNH2 and the rs1805123 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the KCNH2 gene

The following variants in KCNH2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions