rs5219
Variant in the KCNJ11 gene (Potassium Inwardly Rectifying Channel Subfamily J Member 11 (Kir6.2))
rs5219 is a single nucleotide polymorphism (SNP) in the KCNJ11 gene, involved in pancreatic ATP-sensitive potassium channel. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs5219 variant?
rs5219 is a SNP (single nucleotide polymorphism) in the KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11 (Kir6.2)) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. KCNJ11 encodes Kir6.2, the pore-forming subunit of the pancreatic ATP-sensitive K+ channel (KATP), critical for glucose-stimulated insulin secretion.
Biological role and pathway
This variant sits within the KCNJ11 gene, which is involved in the pancreatic ATP-sensitive potassium channel pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs5219 and Long COVID / ME-CFS research
KCNJ11 E23K is a common T2D risk variant affecting beta cell insulin secretion; post-COVID diabetes may be influenced by this variant in COVID-19 patients.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: KCNJ11
rs5219 is one of 2 known variants in the KCNJ11 gene. To understand the full biological context of this variant, explore the parent gene page.
View KCNJ11 gene page →Conditions studied in relation to rs5219
Research into KCNJ11 variants including rs5219 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KCNJ11 and the rs5219 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the KCNJ11 gene
The following variants in KCNJ11 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs5219 variant in the KCNJ11 gene?
rs5219 is a single nucleotide polymorphism (SNP) located in the KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11 (Kir6.2)) gene, which is involved in pancreatic ATP-sensitive potassium channel. KCNJ11 encodes Kir6.2, the pore-forming subunit of the pancreatic ATP-sensitive K+ channel (KATP), critical for glucose-stimulated insulin secretion.
How may the rs5219 variant relate to Long COVID or ME/CFS?
KCNJ11 E23K is a common T2D risk variant affecting beta cell insulin secretion; post-COVID diabetes may be influenced by this variant in COVID-19 patients.
Can a consumer DNA test detect the rs5219 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs5219 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for KCNJ11 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]NEJM