rs149899650

What is the rs149899650 variant?

rs149899650 is a SNP (single nucleotide polymorphism) in the KCNJ2 (Potassium Inwardly Rectifying Channel Subfamily J Member 2 (Kir2.1)) gene. It belongs to the Cardiovascular category and is part of the Autonomic Nervous System biological cluster. KCNJ2 encodes Kir2.1, an inward rectifier K+ channel maintaining the cardiac resting membrane potential; mutations cause Andersen-Tawil syndrome.

Biological role and pathway

This variant sits within the KCNJ2 gene, which is involved in the cardiac inward rectifier / resting potential pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: KCNJ2

rs149899650 is one of 1 known variant in the KCNJ2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs149899650

Research into KCNJ2 variants including rs149899650 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KCNJ2 and the rs149899650 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions