rs5020736

What is the rs5020736 variant?

rs5020736 is a SNP (single nucleotide polymorphism) in the KCNMA1 (Potassium Calcium-Activated Channel Subfamily M Alpha 1 (BKCa)) gene. It belongs to the Autonomic category and is part of the Autonomic Nervous System biological cluster. KCNMA1 encodes the BKCa channel, which regulates vascular smooth muscle tone, neuronal excitability, and aldosterone secretion.

Biological role and pathway

This variant sits within the KCNMA1 gene, which is involved in the calcium-activated potassium signaling pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: KCNMA1

rs5020736 is one of 1 known variant in the KCNMA1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs5020736

Research into KCNMA1 variants including rs5020736 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KCNMA1 and the rs5020736 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions