rs163182

What is the rs163182 variant?

rs163182 is a SNP (single nucleotide polymorphism) in the KCNQ1 (Potassium Voltage-Gated Channel Subfamily Q Member 1) gene. It belongs to the Autonomic category and is part of the Autonomic Nervous System biological cluster. KCNQ1 encodes a voltage-gated potassium channel critical for cardiac repolarization and epithelial ion transport.

Biological role and pathway

This variant sits within the KCNQ1 gene, which is involved in the cardiac and epithelial potassium channel pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: KCNQ1

rs163182 is one of 2 known variants in the KCNQ1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs163182

Research into KCNQ1 variants including rs163182 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KCNQ1 and the rs163182 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the KCNQ1 gene

The following variants in KCNQ1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions