rs786200
Variant in the KCNQ2 gene (Potassium Voltage-Gated Channel Subfamily Q Member 2)
rs786200 is a single nucleotide polymorphism (SNP) in the KCNQ2 gene, involved in M-current / neuronal excitability regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs786200 variant?
rs786200 is a SNP (single nucleotide polymorphism) in the KCNQ2 (Potassium Voltage-Gated Channel Subfamily Q Member 2) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. KCNQ2 encodes Kv7.2, a potassium channel component of the M-current that regulates neuronal excitability and inhibits repetitive firing.
Biological role and pathway
This variant sits within the KCNQ2 gene, which is involved in the M-current / neuronal excitability regulation pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs786200 and Long COVID / ME-CFS research
KCNQ2 M-current limits neuronal hyperexcitability; variants may affect the threshold for neurological hypersensitivity and sensory symptoms in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: KCNQ2
rs786200 is one of 1 known variant in the KCNQ2 gene. To understand the full biological context of this variant, explore the parent gene page.
View KCNQ2 gene page →Conditions studied in relation to rs786200
Research into KCNQ2 variants including rs786200 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KCNQ2 and the rs786200 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs786200 variant in the KCNQ2 gene?
rs786200 is a single nucleotide polymorphism (SNP) located in the KCNQ2 (Potassium Voltage-Gated Channel Subfamily Q Member 2) gene, which is involved in M-current / neuronal excitability regulation. KCNQ2 encodes Kv7.2, a potassium channel component of the M-current that regulates neuronal excitability and inhibits repetitive firing.
How may the rs786200 variant relate to Long COVID or ME/CFS?
KCNQ2 M-current limits neuronal hyperexcitability; variants may affect the threshold for neurological hypersensitivity and sensory symptoms in Long COVID.
Can a consumer DNA test detect the rs786200 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs786200 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for KCNQ2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Nature Neuroscience