rs5952505

What is the rs5952505 variant?

rs5952505 is a SNP (single nucleotide polymorphism) in the KDM6A (Lysine Demethylase 6A (UTX)) gene. It belongs to the Epigenetics category and is part of the Methylation & Neurotransmitters biological cluster. KDM6A encodes UTX, an H3K27me3 demethylase that removes PRC2-mediated gene silencing to activate gene expression.

Biological role and pathway

This variant sits within the KDM6A gene, which is involved in the H3K27 demethylation / gene activation pathway. Genes within the Methylation & Neurotransmitters cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: KDM6A

rs5952505 is one of 1 known variant in the KDM6A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs5952505

Research into KDM6A variants including rs5952505 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KDM6A and the rs5952505 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions