rs2071559
Variant in the KDR gene (Kinase Insert Domain Receptor (VEGFR2))
rs2071559 is a single nucleotide polymorphism (SNP) in the KDR gene, involved in VEGF receptor signaling / angiogenesis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2071559 variant?
rs2071559 is a SNP (single nucleotide polymorphism) in the KDR (Kinase Insert Domain Receptor (VEGFR2)) gene. It belongs to the Vascular category and is part of the Coagulation & Microcirculation biological cluster. KDR encodes VEGFR2, the primary signaling receptor for VEGF-A, mediating endothelial cell proliferation, survival, and angiogenesis.
Biological role and pathway
This variant sits within the KDR gene, which is involved in the VEGF receptor signaling / angiogenesis pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2071559 and Long COVID / ME-CFS research
VEGFR2 signaling drives the angiogenic response to COVID-19 hypoxia and injury; KDR variants may affect vascular repair and remodeling in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: KDR
rs2071559 is one of 2 known variants in the KDR gene. To understand the full biological context of this variant, explore the parent gene page.
View KDR gene page →Conditions studied in relation to rs2071559
Research into KDR variants including rs2071559 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KDR and the rs2071559 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the KDR gene
The following variants in KDR are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2071559 variant in the KDR gene?
rs2071559 is a single nucleotide polymorphism (SNP) located in the KDR (Kinase Insert Domain Receptor (VEGFR2)) gene, which is involved in VEGF receptor signaling / angiogenesis. KDR encodes VEGFR2, the primary signaling receptor for VEGF-A, mediating endothelial cell proliferation, survival, and angiogenesis.
How may the rs2071559 variant relate to Long COVID or ME/CFS?
VEGFR2 signaling drives the angiogenic response to COVID-19 hypoxia and injury; KDR variants may affect vascular repair and remodeling in Long COVID.
Can a consumer DNA test detect the rs2071559 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2071559 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for KDR and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]Circulation