rs11038172
Variant in the KLF1 gene (Kruppel Like Factor 1 (EKLF))
rs11038172 is a single nucleotide polymorphism (SNP) in the KLF1 gene, involved in erythroid differentiation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11038172 variant?
rs11038172 is a SNP (single nucleotide polymorphism) in the KLF1 (Kruppel Like Factor 1 (EKLF)) gene. It belongs to the Immune Signaling category and is part of the Coagulation & Microcirculation biological cluster. KLF1 encodes erythroid Kruppel-like factor, a master erythroid transcription factor that regulates hemoglobin and red cell membrane protein expression.
Biological role and pathway
This variant sits within the KLF1 gene, which is involved in the erythroid differentiation pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11038172 and Long COVID / ME-CFS research
KLF1 drives erythroid gene expression; variants may affect red blood cell fragility and the hemolytic changes associated with COVID-19 vascular damage, contributing to Long COVID anemia.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: KLF1
rs11038172 is one of 1 known variant in the KLF1 gene. To understand the full biological context of this variant, explore the parent gene page.
View KLF1 gene page →Conditions studied in relation to rs11038172
Research into KLF1 variants including rs11038172 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KLF1 and the rs11038172 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs11038172 variant in the KLF1 gene?
rs11038172 is a single nucleotide polymorphism (SNP) located in the KLF1 (Kruppel Like Factor 1 (EKLF)) gene, which is involved in erythroid differentiation. KLF1 encodes erythroid Kruppel-like factor, a master erythroid transcription factor that regulates hemoglobin and red cell membrane protein expression.
How may the rs11038172 variant relate to Long COVID or ME/CFS?
KLF1 drives erythroid gene expression; variants may affect red blood cell fragility and the hemolytic changes associated with COVID-19 vascular damage, contributing to Long COVID anemia.
Can a consumer DNA test detect the rs11038172 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11038172 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for KLF1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Blood