rs2304591
Variant in the KLKB1 gene (Plasma Kallikrein)
rs2304591 is a single nucleotide polymorphism (SNP) in the KLKB1 gene, involved in contact activation / bradykinin production. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2304591 variant?
rs2304591 is a SNP (single nucleotide polymorphism) in the KLKB1 (Plasma Kallikrein) gene. It belongs to the Coagulation category and is part of the Coagulation & Microcirculation biological cluster. KLKB1 encodes plasma prekallikrein (Fletcher factor), which is activated by factor XIIa to generate bradykinin from kininogens.
Biological role and pathway
This variant sits within the KLKB1 gene, which is involved in the contact activation / bradykinin production pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2304591 and Long COVID / ME-CFS research
Plasma kallikrein drives bradykinin production; dysregulated kallikrein-kinin activation may contribute to vascular permeability and dysautonomia in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: KLKB1
rs2304591 is one of 3 known variants in the KLKB1 gene. To understand the full biological context of this variant, explore the parent gene page.
View KLKB1 gene page →Conditions studied in relation to rs2304591
Research into KLKB1 variants including rs2304591 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KLKB1 and the rs2304591 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the KLKB1 gene
The following variants in KLKB1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2304591 variant in the KLKB1 gene?
rs2304591 is a single nucleotide polymorphism (SNP) located in the KLKB1 (Plasma Kallikrein) gene, which is involved in contact activation / bradykinin production. KLKB1 encodes plasma prekallikrein (Fletcher factor), which is activated by factor XIIa to generate bradykinin from kininogens.
How may the rs2304591 variant relate to Long COVID or ME/CFS?
Plasma kallikrein drives bradykinin production; dysregulated kallikrein-kinin activation may contribute to vascular permeability and dysautonomia in Long COVID.
Can a consumer DNA test detect the rs2304591 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2304591 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for KLKB1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]Thrombosis and Haemostasis