rs564481

What is the rs564481 variant?

rs564481 is a SNP (single nucleotide polymorphism) in the KL (Klotho) gene. It belongs to the Neuroendocrine category and is part of the Metabolic Regulation biological cluster. KL encodes klotho, a transmembrane protein that acts as an obligate co-receptor for FGF23 and regulates aging, mineral metabolism, and kidney function.

Biological role and pathway

This variant sits within the KL gene, which is involved in the FGF23 co-receptor / aging / kidney function pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: KL

rs564481 is one of 2 known variants in the KL gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs564481

Research into KL variants including rs564481 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KL and the rs564481 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the KL gene

The following variants in KL are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions