rs4763461
Variant in the KLRB1 gene (Killer Cell Lectin Like Receptor B1 (CD161/NKR-P1))
rs4763461 is a single nucleotide polymorphism (SNP) in the KLRB1 gene, involved in NK cell and T cell regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4763461 variant?
rs4763461 is a SNP (single nucleotide polymorphism) in the KLRB1 (Killer Cell Lectin Like Receptor B1 (CD161/NKR-P1)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. KLRB1 encodes CD161/NKR-P1, a lectin receptor on NK cells and a subset of T cells (MAIT cells, NKT cells) that modulates cytotoxic activity.
Biological role and pathway
This variant sits within the KLRB1 gene, which is involved in the NK cell and T cell regulation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4763461 and Long COVID / ME-CFS research
KLRB1+ MAIT cells and NKT cells are implicated in COVID-19 pathogenesis; variants may affect innate-like T cell responses and immune regulation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: KLRB1
rs4763461 is one of 1 known variant in the KLRB1 gene. To understand the full biological context of this variant, explore the parent gene page.
View KLRB1 gene page →Conditions studied in relation to rs4763461
Research into KLRB1 variants including rs4763461 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KLRB1 and the rs4763461 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs4763461 variant in the KLRB1 gene?
rs4763461 is a single nucleotide polymorphism (SNP) located in the KLRB1 (Killer Cell Lectin Like Receptor B1 (CD161/NKR-P1)) gene, which is involved in NK cell and T cell regulation. KLRB1 encodes CD161/NKR-P1, a lectin receptor on NK cells and a subset of T cells (MAIT cells, NKT cells) that modulates cytotoxic activity.
How may the rs4763461 variant relate to Long COVID or ME/CFS?
KLRB1+ MAIT cells and NKT cells are implicated in COVID-19 pathogenesis; variants may affect innate-like T cell responses and immune regulation in Long COVID.
Can a consumer DNA test detect the rs4763461 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4763461 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for KLRB1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Immunology
- [3]Cell