rs7945685
Variant in the KLRD1 gene (Killer Cell Lectin Like Receptor D1)
rs7945685 is a single nucleotide polymorphism (SNP) in the KLRD1 gene, involved in NK cell function. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs7945685 variant?
rs7945685 is a SNP (single nucleotide polymorphism) in the KLRD1 (Killer Cell Lectin Like Receptor D1) gene. It belongs to the Adaptive Immunity category and is part of the Adaptive Immunity biological cluster. KLRD1 (CD94) forms heterodimers with NKG2A or NKG2C on NK cells. CD94/NKG2A recognizes HLA-E to inhibit NK cell killing; CD94/NKG2C activates NK cells in CMV-infected and transformed cells.
Biological role and pathway
This variant sits within the KLRD1 gene, which is involved in the NK cell function pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs7945685 and Long COVID / ME-CFS research
NK cell dysfunction including altered NKG2A/NKG2C balance is documented in Long COVID, with persistent NKG2A-expressing adaptive NK cells. KLRD1 variants affecting CD94-NKG2 interactions may influence the NK cell activation threshold relevant to viral reservoir surveillance in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: KLRD1
rs7945685 is one of 2 known variants in the KLRD1 gene. To understand the full biological context of this variant, explore the parent gene page.
View KLRD1 gene page →Conditions studied in relation to rs7945685
Research into KLRD1 variants including rs7945685 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KLRD1 and the rs7945685 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the KLRD1 gene
The following variants in KLRD1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs7945685 variant in the KLRD1 gene?
rs7945685 is a single nucleotide polymorphism (SNP) located in the KLRD1 (Killer Cell Lectin Like Receptor D1) gene, which is involved in NK cell function. KLRD1 (CD94) forms heterodimers with NKG2A or NKG2C on NK cells. CD94/NKG2A recognizes HLA-E to inhibit NK cell killing; CD94/NKG2C activates NK cells in CMV-infected and transformed cells.
How may the rs7945685 variant relate to Long COVID or ME/CFS?
NK cell dysfunction including altered NKG2A/NKG2C balance is documented in Long COVID, with persistent NKG2A-expressing adaptive NK cells. KLRD1 variants affecting CD94-NKG2 interactions may influence the NK cell activation threshold relevant to viral reservoir surveillance in Long COVID.
Can a consumer DNA test detect the rs7945685 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs7945685 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for KLRD1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33827926
- [2]Nature Immunology
- [3]Cell Reports