rs5030062
Variant in the KNG1 gene (Kininogen 1)
rs5030062 is a single nucleotide polymorphism (SNP) in the KNG1 gene, involved in contact activation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs5030062 variant?
rs5030062 is a SNP (single nucleotide polymorphism) in the KNG1 (Kininogen 1) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. High-molecular-weight kininogen (HK) is the precursor for bradykinin, cleaved by kallikrein. It also participates in contact activation of coagulation and provides a surface for assembly of the intrinsic tenase complex.
Biological role and pathway
This variant sits within the KNG1 gene, which is involved in the contact activation pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs5030062 and Long COVID / ME-CFS research
HK cleavage by kallikrein releases bradykinin contributing to COVID-19-associated vascular permeability and hypotension. KNG1 variants affecting HK levels or kallikrein cleavage susceptibility may modulate the bradykinin excess underlying Long COVID vascular symptoms.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: KNG1
rs5030062 is one of 3 known variants in the KNG1 gene. To understand the full biological context of this variant, explore the parent gene page.
View KNG1 gene page →Conditions studied in relation to rs5030062
Research into KNG1 variants including rs5030062 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KNG1 and the rs5030062 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the KNG1 gene
The following variants in KNG1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs5030062 variant in the KNG1 gene?
rs5030062 is a single nucleotide polymorphism (SNP) located in the KNG1 (Kininogen 1) gene, which is involved in contact activation. High-molecular-weight kininogen (HK) is the precursor for bradykinin, cleaved by kallikrein. It also participates in contact activation of coagulation and provides a surface for assembly of the intrinsic tenase complex.
How may the rs5030062 variant relate to Long COVID or ME/CFS?
HK cleavage by kallikrein releases bradykinin contributing to COVID-19-associated vascular permeability and hypotension. KNG1 variants affecting HK levels or kallikrein cleavage susceptibility may modulate the bradykinin excess underlying Long COVID vascular symptoms.
Can a consumer DNA test detect the rs5030062 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs5030062 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for KNG1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32826326
- [2]Blood
- [3]Journal of Thrombosis and Haemostasis