rs1065369

What is the rs1065369 variant?

rs1065369 is a SNP (single nucleotide polymorphism) in the KYNU (Kynureninase) gene. It belongs to the Metabolic category and is part of the Methylation & Neurotransmitters biological cluster. KYNU encodes kynureninase, which converts kynurenine to anthranilic acid or 3-hydroxykynurenine, a precursor to NAD+ via the de novo pathway.

Biological role and pathway

This variant sits within the KYNU gene, which is involved in the kynurenine pathway / NAD+ synthesis pathway. Genes within the Methylation & Neurotransmitters cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: KYNU

rs1065369 is one of 1 known variant in the KYNU gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1065369

Research into KYNU variants including rs1065369 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KYNU and the rs1065369 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions