rs2232582

What is the rs2232582 variant?

rs2232582 is a SNP (single nucleotide polymorphism) in the LBP (Lipopolysaccharide Binding Protein) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. LBP encodes lipopolysaccharide-binding protein, which transfers LPS to CD14 to initiate TLR4-mediated macrophage activation.

Biological role and pathway

This variant sits within the LBP gene, which is involved in the LPS detection / innate immune activation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: LBP

rs2232582 is one of 1 known variant in the LBP gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2232582

Research into LBP variants including rs2232582 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include LBP and the rs2232582 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions