rs4144979

What is the rs4144979 variant?

rs4144979 is a SNP (single nucleotide polymorphism) in the LDHA (Lactate Dehydrogenase A) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. LDHA encodes the LDH-A subunit, which catalyzes the conversion of pyruvate to lactate under anaerobic or high-flux glycolytic conditions.

Biological role and pathway

This variant sits within the LDHA gene, which is involved in the anaerobic glycolysis pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: LDHA

rs4144979 is one of 1 known variant in the LDHA gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs4144979

Research into LDHA variants including rs4144979 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include LDHA and the rs4144979 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions