rs1805094
Variant in the LEPR gene (Leptin Receptor)
rs1805094 is a single nucleotide polymorphism (SNP) in the LEPR gene, involved in leptin / energy homeostasis signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1805094 variant?
rs1805094 is a SNP (single nucleotide polymorphism) in the LEPR (Leptin Receptor) gene. It belongs to the Neuroendocrine category and is part of the Metabolic Regulation biological cluster. LEPR encodes the leptin receptor, mediating leptin's effects on appetite suppression, energy expenditure, and immune function.
Biological role and pathway
This variant sits within the LEPR gene, which is involved in the leptin / energy homeostasis signaling pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1805094 and Long COVID / ME-CFS research
Leptin is pro-inflammatory and its signaling through LEPR influences immune cell function; LEPR variants may affect the inflammatory state and fatigue in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: LEPR
rs1805094 is one of 2 known variants in the LEPR gene. To understand the full biological context of this variant, explore the parent gene page.
View LEPR gene page →Conditions studied in relation to rs1805094
Research into LEPR variants including rs1805094 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include LEPR and the rs1805094 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the LEPR gene
The following variants in LEPR are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1805094 variant in the LEPR gene?
rs1805094 is a single nucleotide polymorphism (SNP) located in the LEPR (Leptin Receptor) gene, which is involved in leptin / energy homeostasis signaling. LEPR encodes the leptin receptor, mediating leptin's effects on appetite suppression, energy expenditure, and immune function.
How may the rs1805094 variant relate to Long COVID or ME/CFS?
Leptin is pro-inflammatory and its signaling through LEPR influences immune cell function; LEPR variants may affect the inflammatory state and fatigue in Long COVID.
Can a consumer DNA test detect the rs1805094 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1805094 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for LEPR and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]Journal of Immunology