rs4775041
Variant in the LIPC gene (Lipase C, Hepatic Type)
rs4775041 is a single nucleotide polymorphism (SNP) in the LIPC gene, involved in HDL remodeling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4775041 variant?
rs4775041 is a SNP (single nucleotide polymorphism) in the LIPC (Lipase C, Hepatic Type) gene. It belongs to the Metabolism category and is part of the Mitochondrial & Metabolic biological cluster. Hepatic lipase (LIPC) hydrolyzes triglycerides and phospholipids in IDL, LDL, and HDL particles, facilitating their hepatic uptake and converting HDL2 to HDL3. It influences both LDL particle size and HDL levels.
Biological role and pathway
This variant sits within the LIPC gene, which is involved in the HDL remodeling pathway. Genes within the Mitochondrial & Metabolic cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4775041 and Long COVID / ME-CFS research
LIPC variants affecting HDL2 catabolism influence mature HDL particle availability and anti-inflammatory HDL function. Altered HDL remodeling through LIPC variants may contribute to the lipid dysregulation associated with COVID-19 and Long COVID cardiovascular complications.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: LIPC
rs4775041 is one of 3 known variants in the LIPC gene. To understand the full biological context of this variant, explore the parent gene page.
View LIPC gene page →Conditions studied in relation to rs4775041
Research into LIPC variants including rs4775041 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include LIPC and the rs4775041 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the LIPC gene
The following variants in LIPC are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4775041 variant in the LIPC gene?
rs4775041 is a single nucleotide polymorphism (SNP) located in the LIPC (Lipase C, Hepatic Type) gene, which is involved in HDL remodeling. Hepatic lipase (LIPC) hydrolyzes triglycerides and phospholipids in IDL, LDL, and HDL particles, facilitating their hepatic uptake and converting HDL2 to HDL3. It influences both LDL particle size and HDL levels.
How may the rs4775041 variant relate to Long COVID or ME/CFS?
LIPC variants affecting HDL2 catabolism influence mature HDL particle availability and anti-inflammatory HDL function. Altered HDL remodeling through LIPC variants may contribute to the lipid dysregulation associated with COVID-19 and Long COVID cardiovascular complications.
Can a consumer DNA test detect the rs4775041 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4775041 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for LIPC and its variants. This is not an exhaustive literature review.
- [1]PMID: 25564309
- [2]Nature Genetics
- [3]Arteriosclerosis Thrombosis and Vascular Biology