rs285
Variant in the LPL gene (Lipoprotein Lipase)
rs285 is a single nucleotide polymorphism (SNP) in the LPL gene, involved in triglyceride hydrolysis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs285 variant?
rs285 is a SNP (single nucleotide polymorphism) in the LPL (Lipoprotein Lipase) gene. It belongs to the Metabolism category and is part of the Mitochondrial & Metabolic biological cluster. LPL is the vascular endothelium-anchored lipase that hydrolyzes triglycerides in chylomicrons and VLDL. Variants in LPL and its regulators are among the strongest genetic determinants of plasma triglyceride levels.
Biological role and pathway
This variant sits within the LPL gene, which is involved in the triglyceride hydrolysis pathway. Genes within the Mitochondrial & Metabolic cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs285 and Long COVID / ME-CFS research
Hypertriglyceridemia in COVID-19 may be driven by impaired LPL activity from elevated ANGPTL3/4 and inflammatory cytokines. LPL variants affecting triglyceride clearance may compound the metabolic disruption of COVID-19 and contribute to persistent lipid abnormalities in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: LPL
rs285 is one of 3 known variants in the LPL gene. To understand the full biological context of this variant, explore the parent gene page.
View LPL gene page →Conditions studied in relation to rs285
Research into LPL variants including rs285 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include LPL and the rs285 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the LPL gene
The following variants in LPL are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs285 variant in the LPL gene?
rs285 is a single nucleotide polymorphism (SNP) located in the LPL (Lipoprotein Lipase) gene, which is involved in triglyceride hydrolysis. LPL is the vascular endothelium-anchored lipase that hydrolyzes triglycerides in chylomicrons and VLDL. Variants in LPL and its regulators are among the strongest genetic determinants of plasma triglyceride levels.
How may the rs285 variant relate to Long COVID or ME/CFS?
Hypertriglyceridemia in COVID-19 may be driven by impaired LPL activity from elevated ANGPTL3/4 and inflammatory cytokines. LPL variants affecting triglyceride clearance may compound the metabolic disruption of COVID-19 and contribute to persistent lipid abnormalities in Long COVID.
Can a consumer DNA test detect the rs285 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs285 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for LPL and its variants. This is not an exhaustive literature review.
- [1]PMID: 25564309
- [2]Nature Genetics
- [3]Cell Metabolism