rs34637584

What is the rs34637584 variant?

rs34637584 is a SNP (single nucleotide polymorphism) in the LRRK2 (Leucine Rich Repeat Kinase 2) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. LRRK2 encodes a kinase involved in vesicle trafficking, autophagy, and innate immune function; mutations cause familial Parkinson's disease.

Biological role and pathway

This variant sits within the LRRK2 gene, which is involved in the Parkinson's disease / innate immune regulation pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: LRRK2

rs34637584 is one of 2 known variants in the LRRK2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs34637584

Research into LRRK2 variants including rs34637584 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include LRRK2 and the rs34637584 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the LRRK2 gene

The following variants in LRRK2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions