rs2230949
Variant in the MAPK8 gene (Mitogen-Activated Protein Kinase 8 (JNK1))
rs2230949 is a single nucleotide polymorphism (SNP) in the MAPK8 gene, involved in JNK stress signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2230949 variant?
rs2230949 is a SNP (single nucleotide polymorphism) in the MAPK8 (Mitogen-Activated Protein Kinase 8 (JNK1)) gene. It belongs to the Signaling category and is part of the Cellular Signaling biological cluster. MAPK8 encodes JNK1, a stress-activated MAP kinase that responds to inflammation, oxidative stress, and ER stress.
Biological role and pathway
This variant sits within the MAPK8 gene, which is involved in the JNK stress signaling pathway. Genes within the Cellular Signaling cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2230949 and Long COVID / ME-CFS research
JNK signaling pathway activation by inflammatory cytokines and oxidative stress may contribute to cellular stress responses in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MAPK8
rs2230949 is one of 1 known variant in the MAPK8 gene. To understand the full biological context of this variant, explore the parent gene page.
View MAPK8 gene page →Conditions studied in relation to rs2230949
Research into MAPK8 variants including rs2230949 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MAPK8 and the rs2230949 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MAPK8 gene
The following variants in MAPK8 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2230949 variant in the MAPK8 gene?
rs2230949 is a single nucleotide polymorphism (SNP) located in the MAPK8 (Mitogen-Activated Protein Kinase 8 (JNK1)) gene, which is involved in JNK stress signaling. MAPK8 encodes JNK1, a stress-activated MAP kinase that responds to inflammation, oxidative stress, and ER stress.
How may the rs2230949 variant relate to Long COVID or ME/CFS?
JNK signaling pathway activation by inflammatory cytokines and oxidative stress may contribute to cellular stress responses in Long COVID.
Can a consumer DNA test detect the rs2230949 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2230949 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for MAPK8 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation