rs3785883
Variant in the MAPT gene (Microtubule Associated Protein Tau)
rs3785883 is a single nucleotide polymorphism (SNP) in the MAPT gene, involved in microtubule stability / neurodegeneration. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3785883 variant?
rs3785883 is a SNP (single nucleotide polymorphism) in the MAPT (Microtubule Associated Protein Tau) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. MAPT encodes tau protein, which stabilizes axonal microtubules; hyperphosphorylated tau forms neurofibrillary tangles in Alzheimer's and other tauopathies.
Biological role and pathway
This variant sits within the MAPT gene, which is involved in the microtubule stability / neurodegeneration pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3785883 and Long COVID / ME-CFS research
MAPT haplotypes are risk factors for Alzheimer's and Parkinson's disease; neuroinflammation in Long COVID may accelerate tau pathology, particularly in genetically susceptible individuals.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MAPT
rs3785883 is one of 2 known variants in the MAPT gene. To understand the full biological context of this variant, explore the parent gene page.
View MAPT gene page →Conditions studied in relation to rs3785883
Research into MAPT variants including rs3785883 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MAPT and the rs3785883 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MAPT gene
The following variants in MAPT are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3785883 variant in the MAPT gene?
rs3785883 is a single nucleotide polymorphism (SNP) located in the MAPT (Microtubule Associated Protein Tau) gene, which is involved in microtubule stability / neurodegeneration. MAPT encodes tau protein, which stabilizes axonal microtubules; hyperphosphorylated tau forms neurofibrillary tangles in Alzheimer's and other tauopathies.
How may the rs3785883 variant relate to Long COVID or ME/CFS?
MAPT haplotypes are risk factors for Alzheimer's and Parkinson's disease; neuroinflammation in Long COVID may accelerate tau pathology, particularly in genetically susceptible individuals.
Can a consumer DNA test detect the rs3785883 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3785883 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for MAPT and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]NEJM