rs2837791

What is the rs2837791 variant?

rs2837791 is a SNP (single nucleotide polymorphism) in the MAS1 (MAS Proto-Oncogene G Protein-Coupled Receptor) gene. It belongs to the Cardiovascular category and is part of the Autonomic Nervous System biological cluster. MAS1 encodes the GPCR for angiotensin-(1-7), the ACE2 product that activates the protective arm of the renin-angiotensin system.

Biological role and pathway

This variant sits within the MAS1 gene, which is involved in the ACE2-Ang(1-7)-MAS protective axis pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: MAS1

rs2837791 is one of 1 known variant in the MAS1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2837791

Research into MAS1 variants including rs2837791 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MAS1 and the rs2837791 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions