rs7262903
Variant in the MAVS gene (Mitochondrial Antiviral Signaling Protein)
rs7262903 is a single nucleotide polymorphism (SNP) in the MAVS gene, involved in RLR signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs7262903 variant?
rs7262903 is a SNP (single nucleotide polymorphism) in the MAVS (Mitochondrial Antiviral Signaling Protein) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. MAVS is the mitochondrial outer membrane adaptor protein that aggregates upon RIG-I or MDA5 activation, serving as a signaling platform for IRF3/IRF7 and NF-κB activation. MAVS aggregates are prion-like and self-amplifying.
Biological role and pathway
This variant sits within the MAVS gene, which is involved in the RLR signaling pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs7262903 and Long COVID / ME-CFS research
SARS-CoV-2 protease NSP3 cleaves MAVS to evade antiviral immunity. MAVS variants affecting aggregation dynamics or cleavage susceptibility may alter the efficiency of initial SARS-CoV-2 interferon induction relevant to Long COVID pathogenesis.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MAVS
rs7262903 is one of 3 known variants in the MAVS gene. To understand the full biological context of this variant, explore the parent gene page.
View MAVS gene page →Conditions studied in relation to rs7262903
Research into MAVS variants including rs7262903 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MAVS and the rs7262903 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MAVS gene
The following variants in MAVS are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs7262903 variant in the MAVS gene?
rs7262903 is a single nucleotide polymorphism (SNP) located in the MAVS (Mitochondrial Antiviral Signaling Protein) gene, which is involved in RLR signaling. MAVS is the mitochondrial outer membrane adaptor protein that aggregates upon RIG-I or MDA5 activation, serving as a signaling platform for IRF3/IRF7 and NF-κB activation. MAVS aggregates are prion-like and self-amplifying.
How may the rs7262903 variant relate to Long COVID or ME/CFS?
SARS-CoV-2 protease NSP3 cleaves MAVS to evade antiviral immunity. MAVS variants affecting aggregation dynamics or cleavage susceptibility may alter the efficiency of initial SARS-CoV-2 interferon induction relevant to Long COVID pathogenesis.
Can a consumer DNA test detect the rs7262903 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs7262903 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for MAVS and its variants. This is not an exhaustive literature review.
- [1]PMID: 33514933
- [2]Cell
- [3]Science