rs7096206
Variant in the MBL2 gene (Mannose Binding Lectin 2)
rs7096206 is a single nucleotide polymorphism (SNP) in the MBL2 gene, involved in lectin complement pathway. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs7096206 variant?
rs7096206 is a SNP (single nucleotide polymorphism) in the MBL2 (Mannose Binding Lectin 2) gene. It belongs to the Complement category and is part of the Complement System biological cluster. MBL2 encodes mannose-binding lectin, which activates the complement lectin pathway upon recognition of carbohydrate patterns on pathogens.
Biological role and pathway
This variant sits within the MBL2 gene, which is involved in the lectin complement pathway pathway. Genes within the Complement System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs7096206 and Long COVID / ME-CFS research
MBL2 deficiency impairs early innate responses to SARS-CoV-2 and may influence complement-mediated inflammation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MBL2
rs7096206 is one of 2 known variants in the MBL2 gene. To understand the full biological context of this variant, explore the parent gene page.
View MBL2 gene page →Conditions studied in relation to rs7096206
Research into MBL2 variants including rs7096206 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MBL2 and the rs7096206 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MBL2 gene
The following variants in MBL2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs7096206 variant in the MBL2 gene?
rs7096206 is a single nucleotide polymorphism (SNP) located in the MBL2 (Mannose Binding Lectin 2) gene, which is involved in lectin complement pathway. MBL2 encodes mannose-binding lectin, which activates the complement lectin pathway upon recognition of carbohydrate patterns on pathogens.
How may the rs7096206 variant relate to Long COVID or ME/CFS?
MBL2 deficiency impairs early innate responses to SARS-CoV-2 and may influence complement-mediated inflammation in Long COVID.
Can a consumer DNA test detect the rs7096206 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs7096206 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for MBL2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32972995
- [2]Nature Genetics
- [3]Journal of Clinical Investigation