rs2236911

What is the rs2236911 variant?

rs2236911 is a SNP (single nucleotide polymorphism) in the MFN2 (Mitofusin 2) gene. It belongs to the Mitochondrial Dynamics category and is part of the Mitochondrial Energy Production & PEM biological cluster. MFN2 encodes mitofusin 2, an outer mitochondrial membrane GTPase essential for mitochondrial fusion and maintenance of mitochondrial network integrity.

Biological role and pathway

This variant sits within the MFN2 gene, which is involved in the mitochondrial fusion pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: MFN2

rs2236911 is one of 1 known variant in the MFN2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2236911

Research into MFN2 variants including rs2236911 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MFN2 and the rs2236911 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions