rs1247728

What is the rs1247728 variant?

rs1247728 is a SNP (single nucleotide polymorphism) in the MGLL (Monoglyceride Lipase) gene. It belongs to the Pain Sensory category and is part of the Pain & Sensory Processing biological cluster. MGLL encodes monoacylglycerol lipase, which degrades 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid.

Biological role and pathway

This variant sits within the MGLL gene, which is involved in the endocannabinoid metabolism pathway. Genes within the Pain & Sensory Processing cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: MGLL

rs1247728 is one of 1 known variant in the MGLL gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1247728

Research into MGLL variants including rs1247728 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MGLL and the rs1247728 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions