rs1051792
Variant in the MICA gene (MHC Class I Polypeptide Related Sequence A)
rs1051792 is a single nucleotide polymorphism (SNP) in the MICA gene, involved in NK and CD8 T cell stress recognition. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1051792 variant?
rs1051792 is a SNP (single nucleotide polymorphism) in the MICA (MHC Class I Polypeptide Related Sequence A) gene. It belongs to the Immune Signaling category and is part of the HLA & Immune Presentation biological cluster. MICA encodes a stress-induced ligand for NKG2D on NK cells and CD8+ T cells, expressed on infected or stressed cells.
Biological role and pathway
This variant sits within the MICA gene, which is involved in the NK and CD8 T cell stress recognition pathway. Genes within the HLA & Immune Presentation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1051792 and Long COVID / ME-CFS research
MICA is a key NKG2D ligand on virus-infected cells; MICA variants, particularly rs2596542 and the MICA*008 allele, may affect NK cell-mediated viral clearance in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MICA
rs1051792 is one of 3 known variants in the MICA gene. To understand the full biological context of this variant, explore the parent gene page.
View MICA gene page →Conditions studied in relation to rs1051792
Research into MICA variants including rs1051792 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MICA and the rs1051792 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MICA gene
The following variants in MICA are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1051792 variant in the MICA gene?
rs1051792 is a single nucleotide polymorphism (SNP) located in the MICA (MHC Class I Polypeptide Related Sequence A) gene, which is involved in NK and CD8 T cell stress recognition. MICA encodes a stress-induced ligand for NKG2D on NK cells and CD8+ T cells, expressed on infected or stressed cells.
How may the rs1051792 variant relate to Long COVID or ME/CFS?
MICA is a key NKG2D ligand on virus-infected cells; MICA variants, particularly rs2596542 and the MICA*008 allele, may affect NK cell-mediated viral clearance in Long COVID.
Can a consumer DNA test detect the rs1051792 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1051792 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for MICA and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Journal of Immunology