rs9827643

What is the rs9827643 variant?

rs9827643 is a SNP (single nucleotide polymorphism) in the MLKL (Mixed Lineage Kinase Domain Like Pseudokinase) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. MLKL encodes the terminal necroptosis effector that, when phosphorylated by RIPK3, oligomerizes and permeabilizes the plasma membrane.

Biological role and pathway

This variant sits within the MLKL gene, which is involved in the necroptosis execution pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: MLKL

rs9827643 is one of 1 known variant in the MLKL gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs9827643

Research into MLKL variants including rs9827643 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MLKL and the rs9827643 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions