rs243865
Variant in the MMP2 gene (Matrix Metallopeptidase 2 (Gelatinase A))
rs243865 is a single nucleotide polymorphism (SNP) in the MMP2 gene, involved in extracellular matrix remodeling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs243865 variant?
rs243865 is a SNP (single nucleotide polymorphism) in the MMP2 (Matrix Metallopeptidase 2 (Gelatinase A)) gene. It belongs to the Connective Tissue category and is part of the Coagulation & Microcirculation biological cluster. MMP2 encodes gelatinase A, a matrix metalloproteinase that degrades collagen IV and gelatin, regulating ECM remodeling.
Biological role and pathway
This variant sits within the MMP2 gene, which is involved in the extracellular matrix remodeling pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs243865 and Long COVID / ME-CFS research
MMP2 mediates tissue remodeling during inflammation; elevated MMP2 in COVID-19 contributes to tissue damage and fibrosis that may persist in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MMP2
rs243865 is one of 2 known variants in the MMP2 gene. To understand the full biological context of this variant, explore the parent gene page.
View MMP2 gene page →Conditions studied in relation to rs243865
Research into MMP2 variants including rs243865 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MMP2 and the rs243865 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MMP2 gene
The following variants in MMP2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs243865 variant in the MMP2 gene?
rs243865 is a single nucleotide polymorphism (SNP) located in the MMP2 (Matrix Metallopeptidase 2 (Gelatinase A)) gene, which is involved in extracellular matrix remodeling. MMP2 encodes gelatinase A, a matrix metalloproteinase that degrades collagen IV and gelatin, regulating ECM remodeling.
How may the rs243865 variant relate to Long COVID or ME/CFS?
MMP2 mediates tissue remodeling during inflammation; elevated MMP2 in COVID-19 contributes to tissue damage and fibrosis that may persist in Long COVID.
Can a consumer DNA test detect the rs243865 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs243865 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for MMP2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]Matrix Biology