rs34764364
Variant in the MRC1 gene (Mannose Receptor C-Type 1 (CD206))
rs34764364 is a single nucleotide polymorphism (SNP) in the MRC1 gene, involved in anti-inflammatory macrophage marker / endocytosis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs34764364 variant?
rs34764364 is a SNP (single nucleotide polymorphism) in the MRC1 (Mannose Receptor C-Type 1 (CD206)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. MRC1 encodes the mannose receptor (CD206), expressed on alternatively activated macrophages, mediating endocytosis of mannose-rich pathogens.
Biological role and pathway
This variant sits within the MRC1 gene, which is involved in the anti-inflammatory macrophage marker / endocytosis pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs34764364 and Long COVID / ME-CFS research
CD206+ M2 macrophages are involved in tissue repair and fibrosis; MRC1 variants may affect macrophage polarization toward pro-fibrotic states relevant to Long COVID tissue damage.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MRC1
rs34764364 is one of 1 known variant in the MRC1 gene. To understand the full biological context of this variant, explore the parent gene page.
View MRC1 gene page →Conditions studied in relation to rs34764364
Research into MRC1 variants including rs34764364 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MRC1 and the rs34764364 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs34764364 variant in the MRC1 gene?
rs34764364 is a single nucleotide polymorphism (SNP) located in the MRC1 (Mannose Receptor C-Type 1 (CD206)) gene, which is involved in anti-inflammatory macrophage marker / endocytosis. MRC1 encodes the mannose receptor (CD206), expressed on alternatively activated macrophages, mediating endocytosis of mannose-rich pathogens.
How may the rs34764364 variant relate to Long COVID or ME/CFS?
CD206+ M2 macrophages are involved in tissue repair and fibrosis; MRC1 variants may affect macrophage polarization toward pro-fibrotic states relevant to Long COVID tissue damage.
Can a consumer DNA test detect the rs34764364 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs34764364 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for MRC1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Journal of Experimental Medicine