rs1805087

What is the rs1805087 variant?

rs1805087 is a SNP (single nucleotide polymorphism) in the MTR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase) gene. It belongs to the Methylation category and is part of the Methylation & Neurotransmitters biological cluster. MTR encodes methionine synthase, a vitamin B12-dependent enzyme that remethylates homocysteine to methionine.

Biological role and pathway

This variant sits within the MTR gene, which is involved in the one-carbon metabolism pathway. Genes within the Methylation & Neurotransmitters cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: MTR

rs1805087 is one of 1 known variant in the MTR gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1805087

Research into MTR variants including rs1805087 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MTR and the rs1805087 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions