rs28934889

What is the rs28934889 variant?

rs28934889 is a SNP (single nucleotide polymorphism) in the MUT (Methylmalonyl-CoA Mutase) gene. It belongs to the Metabolic category and is part of the Methylation & Neurotransmitters biological cluster. MUT encodes methylmalonyl-CoA mutase, a B12-dependent enzyme that converts methylmalonyl-CoA to succinyl-CoA for entry into the TCA cycle.

Biological role and pathway

This variant sits within the MUT gene, which is involved in the B12-dependent organic acid metabolism pathway. Genes within the Methylation & Neurotransmitters cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: MUT

rs28934889 is one of 1 known variant in the MUT gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs28934889

Research into MUT variants including rs28934889 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MUT and the rs28934889 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions