rs469390

What is the rs469390 variant?

rs469390 is a SNP (single nucleotide polymorphism) in the MX2 (MX Dynamin-Like GTPase 2) gene. It belongs to the Viral Defense category and is part of the Viral Defense & Interferon Response biological cluster. MX2 encodes a nuclear dynamin-like GTPase induced by interferons that restricts retroviruses and other RNA viruses.

Biological role and pathway

This variant sits within the MX2 gene, which is involved in the interferon-stimulated gene response pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: MX2

rs469390 is one of 1 known variant in the MX2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs469390

Research into MX2 variants including rs469390 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MX2 and the rs469390 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the MX2 gene

The following variants in MX2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions