rs61733415
Variant in the MYD88 gene (MYD88 Innate Immune Signal Transduction Adaptor)
rs61733415 is a single nucleotide polymorphism (SNP) in the MYD88 gene, involved in TLR signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs61733415 variant?
rs61733415 is a SNP (single nucleotide polymorphism) in the MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. MyD88 is the universal adaptor protein for most Toll-like receptors and IL-1 family receptors. It recruits IRAK kinases to activate NF-κB and MAPK pathways. Inherited MyD88 deficiency causes susceptibility to invasive pneumococcal disease.
Biological role and pathway
This variant sits within the MYD88 gene, which is involved in the TLR signaling pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs61733415 and Long COVID / ME-CFS research
MYD88 variants affecting TLR-IL1R signaling may influence COVID-19 susceptibility and the sustained innate immune activation driving Long COVID. Gain-of-function MYD88 mutations are known oncogenic drivers, while loss-of-function increases infection susceptibility.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MYD88
rs61733415 is one of 3 known variants in the MYD88 gene. To understand the full biological context of this variant, explore the parent gene page.
View MYD88 gene page →Conditions studied in relation to rs61733415
Research into MYD88 variants including rs61733415 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MYD88 and the rs61733415 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MYD88 gene
The following variants in MYD88 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs61733415 variant in the MYD88 gene?
rs61733415 is a single nucleotide polymorphism (SNP) located in the MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) gene, which is involved in TLR signaling. MyD88 is the universal adaptor protein for most Toll-like receptors and IL-1 family receptors. It recruits IRAK kinases to activate NF-κB and MAPK pathways. Inherited MyD88 deficiency causes susceptibility to invasive pneumococcal disease.
How may the rs61733415 variant relate to Long COVID or ME/CFS?
MYD88 variants affecting TLR-IL1R signaling may influence COVID-19 susceptibility and the sustained innate immune activation driving Long COVID. Gain-of-function MYD88 mutations are known oncogenic drivers, while loss-of-function increases infection susceptibility.
Can a consumer DNA test detect the rs61733415 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs61733415 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for MYD88 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29429640
- [2]Nature Reviews Immunology
- [3]Journal of Experimental Medicine