rs877724
Variant in the MYL9 gene (Myosin Light Chain 9)
rs877724 is a single nucleotide polymorphism (SNP) in the MYL9 gene, involved in smooth muscle contraction / endothelial contractility. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs877724 variant?
rs877724 is a SNP (single nucleotide polymorphism) in the MYL9 (Myosin Light Chain 9) gene. It belongs to the Signaling category and is part of the Coagulation & Microcirculation biological cluster. MYL9 encodes myosin regulatory light chain 9, which when phosphorylated by MLCK or ROCK2 activates myosin for smooth muscle and endothelial contraction.
Biological role and pathway
This variant sits within the MYL9 gene, which is involved in the smooth muscle contraction / endothelial contractility pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs877724 and Long COVID / ME-CFS research
MYL9 phosphorylation drives endothelial contraction and vascular permeability; variants may affect vascular tone and endothelial barrier function in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MYL9
rs877724 is one of 1 known variant in the MYL9 gene. To understand the full biological context of this variant, explore the parent gene page.
View MYL9 gene page →Conditions studied in relation to rs877724
Research into MYL9 variants including rs877724 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MYL9 and the rs877724 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs877724 variant in the MYL9 gene?
rs877724 is a single nucleotide polymorphism (SNP) located in the MYL9 (Myosin Light Chain 9) gene, which is involved in smooth muscle contraction / endothelial contractility. MYL9 encodes myosin regulatory light chain 9, which when phosphorylated by MLCK or ROCK2 activates myosin for smooth muscle and endothelial contraction.
How may the rs877724 variant relate to Long COVID or ME/CFS?
MYL9 phosphorylation drives endothelial contraction and vascular permeability; variants may affect vascular tone and endothelial barrier function in Long COVID.
Can a consumer DNA test detect the rs877724 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs877724 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for MYL9 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]Circulation