rs4986782

What is the rs4986782 variant?

rs4986782 is a SNP (single nucleotide polymorphism) in the NAT1 (N-Acetyltransferase 1) gene. It belongs to the Pharmacogenomics category and is part of the Detox & Medication Sensitivity biological cluster. NAT1 encodes N-acetyltransferase 1, which acetylates arylamine drugs and endogenous compounds in many tissues.

Biological role and pathway

This variant sits within the NAT1 gene, which is involved in the arylamine N-acetyltransferase / drug metabolism pathway. Genes within the Detox & Medication Sensitivity cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: NAT1

rs4986782 is one of 2 known variants in the NAT1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs4986782

Research into NAT1 variants including rs4986782 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NAT1 and the rs4986782 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the NAT1 gene

The following variants in NAT1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions