rs1041983
Variant in the NAT2 gene (N-Acetyltransferase 2)
rs1041983 is a single nucleotide polymorphism (SNP) in the NAT2 gene, involved in drug metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1041983 variant?
rs1041983 is a SNP (single nucleotide polymorphism) in the NAT2 (N-Acetyltransferase 2) gene. It belongs to the Metabolism category and is part of the Pharmacogenomics biological cluster. NAT2 catalyzes N-acetylation of aromatic amines and hydrazines. Variants define slow, intermediate, and rapid acetylator phenotypes that strongly affect metabolism of isoniazid, sulfonamides, caffeine, and other drugs.
Biological role and pathway
This variant sits within the NAT2 gene, which is involved in the drug metabolism pathway. Genes within the Pharmacogenomics cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1041983 and Long COVID / ME-CFS research
NAT2 slow acetylators may have altered metabolism of some anti-infective agents. The acetylator phenotype also influences susceptibility to environmental chemical-induced oxidative stress, potentially relevant to the chemical sensitivity reported in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NAT2
rs1041983 is one of 4 known variants in the NAT2 gene. To understand the full biological context of this variant, explore the parent gene page.
View NAT2 gene page →Conditions studied in relation to rs1041983
Research into NAT2 variants including rs1041983 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NAT2 and the rs1041983 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the NAT2 gene
The following variants in NAT2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1041983 variant in the NAT2 gene?
rs1041983 is a single nucleotide polymorphism (SNP) located in the NAT2 (N-Acetyltransferase 2) gene, which is involved in drug metabolism. NAT2 catalyzes N-acetylation of aromatic amines and hydrazines. Variants define slow, intermediate, and rapid acetylator phenotypes that strongly affect metabolism of isoniazid, sulfonamides, caffeine, and other drugs.
How may the rs1041983 variant relate to Long COVID or ME/CFS?
NAT2 slow acetylators may have altered metabolism of some anti-infective agents. The acetylator phenotype also influences susceptibility to environmental chemical-induced oxidative stress, potentially relevant to the chemical sensitivity reported in Long COVID.
Can a consumer DNA test detect the rs1041983 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1041983 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NAT2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 25925009
- [2]Pharmacogenomics
- [3]Annual Review of Pharmacology and Toxicology