rs11676839
Variant in the NDUFS7 gene (NADH:Ubiquinone Oxidoreductase Core Subunit S7)
rs11676839 is a single nucleotide polymorphism (SNP) in the NDUFS7 gene, involved in oxidative phosphorylation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11676839 variant?
rs11676839 is a SNP (single nucleotide polymorphism) in the NDUFS7 (NADH:Ubiquinone Oxidoreductase Core Subunit S7) gene. It belongs to the Mitochondrial category and is part of the Mitochondrial Energy Production & PEM biological cluster. NDUFS7 encodes a core subunit of mitochondrial Complex I, the primary entry point of electrons in the respiratory chain.
Biological role and pathway
This variant sits within the NDUFS7 gene, which is involved in the oxidative phosphorylation pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11676839 and Long COVID / ME-CFS research
Complex I dysfunction may contribute to impaired ATP production and the fatigue and post-exertional malaise characteristic of Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NDUFS7
rs11676839 is one of 1 known variant in the NDUFS7 gene. To understand the full biological context of this variant, explore the parent gene page.
View NDUFS7 gene page →Conditions studied in relation to rs11676839
Research into NDUFS7 variants including rs11676839 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NDUFS7 and the rs11676839 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs11676839 variant in the NDUFS7 gene?
rs11676839 is a single nucleotide polymorphism (SNP) located in the NDUFS7 (NADH:Ubiquinone Oxidoreductase Core Subunit S7) gene, which is involved in oxidative phosphorylation. NDUFS7 encodes a core subunit of mitochondrial Complex I, the primary entry point of electrons in the respiratory chain.
How may the rs11676839 variant relate to Long COVID or ME/CFS?
Complex I dysfunction may contribute to impaired ATP production and the fatigue and post-exertional malaise characteristic of Long COVID.
Can a consumer DNA test detect the rs11676839 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11676839 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NDUFS7 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32735956
- [2]Nature Genetics
- [3]Journal of Clinical Investigation