rs1056949
Variant in the NDUFV1 gene (NADH:Ubiquinone Oxidoreductase Core Subunit V1)
rs1056949 is a single nucleotide polymorphism (SNP) in the NDUFV1 gene, involved in oxidative phosphorylation Complex I. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1056949 variant?
rs1056949 is a SNP (single nucleotide polymorphism) in the NDUFV1 (NADH:Ubiquinone Oxidoreductase Core Subunit V1) gene. It belongs to the Mitochondrial category and is part of the Mitochondrial Energy Production & PEM biological cluster. NDUFV1 encodes the flavoprotein subunit of Complex I that binds NADH and is essential for electron transfer to ubiquinone.
Biological role and pathway
This variant sits within the NDUFV1 gene, which is involved in the oxidative phosphorylation Complex I pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1056949 and Long COVID / ME-CFS research
NDUFV1 function is critical for Complex I NADH oxidation; variants may reduce mitochondrial ATP generation contributing to Long COVID fatigue.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NDUFV1
rs1056949 is one of 1 known variant in the NDUFV1 gene. To understand the full biological context of this variant, explore the parent gene page.
View NDUFV1 gene page →Conditions studied in relation to rs1056949
Research into NDUFV1 variants including rs1056949 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NDUFV1 and the rs1056949 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs1056949 variant in the NDUFV1 gene?
rs1056949 is a single nucleotide polymorphism (SNP) located in the NDUFV1 (NADH:Ubiquinone Oxidoreductase Core Subunit V1) gene, which is involved in oxidative phosphorylation Complex I. NDUFV1 encodes the flavoprotein subunit of Complex I that binds NADH and is essential for electron transfer to ubiquinone.
How may the rs1056949 variant relate to Long COVID or ME/CFS?
NDUFV1 function is critical for Complex I NADH oxidation; variants may reduce mitochondrial ATP generation contributing to Long COVID fatigue.
Can a consumer DNA test detect the rs1056949 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1056949 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NDUFV1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32735956
- [2]Nature Genetics
- [3]Journal of Clinical Investigation