rs696
Variant in the NFKBIA gene (NFKB Inhibitor Alpha (IkB-alpha))
rs696 is a single nucleotide polymorphism (SNP) in the NFKBIA gene, involved in NF-kB negative regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs696 variant?
rs696 is a SNP (single nucleotide polymorphism) in the NFKBIA (NFKB Inhibitor Alpha (IkB-alpha)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. NFKBIA encodes IκBα, the primary cytoplasmic inhibitor of NF-kB that sequesters NF-kB dimers and prevents nuclear translocation.
Biological role and pathway
This variant sits within the NFKBIA gene, which is involved in the NF-kB negative regulation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs696 and Long COVID / ME-CFS research
NFKBIA restrains NF-kB inflammatory signaling; variants affecting IκBα stability or expression may alter inflammatory signal amplitude and contribute to sustained inflammation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NFKBIA
rs696 is one of 2 known variants in the NFKBIA gene. To understand the full biological context of this variant, explore the parent gene page.
View NFKBIA gene page →Conditions studied in relation to rs696
Research into NFKBIA variants including rs696 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NFKBIA and the rs696 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the NFKBIA gene
The following variants in NFKBIA are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs696 variant in the NFKBIA gene?
rs696 is a single nucleotide polymorphism (SNP) located in the NFKBIA (NFKB Inhibitor Alpha (IkB-alpha)) gene, which is involved in NF-kB negative regulation. NFKBIA encodes IκBα, the primary cytoplasmic inhibitor of NF-kB that sequesters NF-kB dimers and prevents nuclear translocation.
How may the rs696 variant relate to Long COVID or ME/CFS?
NFKBIA restrains NF-kB inflammatory signaling; variants affecting IκBα stability or expression may alter inflammatory signal amplitude and contribute to sustained inflammation in Long COVID.
Can a consumer DNA test detect the rs696 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs696 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NFKBIA and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Science