rs1805902
Variant in the NEFL gene (Neurofilament Light Chain)
rs1805902 is a single nucleotide polymorphism (SNP) in the NEFL gene, involved in axon structural integrity / neurodegeneration biomarker. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1805902 variant?
rs1805902 is a SNP (single nucleotide polymorphism) in the NEFL (Neurofilament Light Chain) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. NEFL encodes neurofilament light chain, the most abundant neurofilament protein; serum NfL is a sensitive biomarker of axonal injury and neurodegeneration.
Biological role and pathway
This variant sits within the NEFL gene, which is involved in the axon structural integrity / neurodegeneration biomarker pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1805902 and Long COVID / ME-CFS research
Serum neurofilament light (NfL) is elevated in Long COVID patients with neurological symptoms, reflecting axonal damage; NEFL variants may affect neuronal fragility and Long COVID neurological outcomes.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NEFL
rs1805902 is one of 1 known variant in the NEFL gene. To understand the full biological context of this variant, explore the parent gene page.
View NEFL gene page →Conditions studied in relation to rs1805902
Research into NEFL variants including rs1805902 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NEFL and the rs1805902 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs1805902 variant in the NEFL gene?
rs1805902 is a single nucleotide polymorphism (SNP) located in the NEFL (Neurofilament Light Chain) gene, which is involved in axon structural integrity / neurodegeneration biomarker. NEFL encodes neurofilament light chain, the most abundant neurofilament protein; serum NfL is a sensitive biomarker of axonal injury and neurodegeneration.
How may the rs1805902 variant relate to Long COVID or ME/CFS?
Serum neurofilament light (NfL) is elevated in Long COVID patients with neurological symptoms, reflecting axonal damage; NEFL variants may affect neuronal fragility and Long COVID neurological outcomes.
Can a consumer DNA test detect the rs1805902 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1805902 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NEFL and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Medicine
- [3]Cell