rs6330

What is the rs6330 variant?

rs6330 is a SNP (single nucleotide polymorphism) in the NGF (Nerve Growth Factor) gene. It belongs to the Neuroplasticity category and is part of the Neurological & Cognitive Function biological cluster. NGF encodes nerve growth factor, the founding member of the neurotrophin family, essential for sympathetic neuron survival and pain sensitization.

Biological role and pathway

This variant sits within the NGF gene, which is involved in the neurotrophin signaling pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: NGF

rs6330 is one of 1 known variant in the NGF gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs6330

Research into NGF variants including rs6330 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NGF and the rs6330 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions