rs6604946
Variant in the NKX2-1 gene (NK2 Homeobox 1 (TTF-1))
rs6604946 is a single nucleotide polymorphism (SNP) in the NKX2-1 gene, involved in lung development / surfactant gene regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs6604946 variant?
rs6604946 is a SNP (single nucleotide polymorphism) in the NKX2-1 (NK2 Homeobox 1 (TTF-1)) gene. It belongs to the Respiratory category and is part of the Respiratory & Lung Function biological cluster. NKX2-1 encodes thyroid transcription factor 1 (TTF-1/NK2.1), the master regulator of lung development and surfactant gene expression in alveolar type II cells.
Biological role and pathway
This variant sits within the NKX2-1 gene, which is involved in the lung development / surfactant gene regulation pathway. Genes within the Respiratory & Lung Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs6604946 and Long COVID / ME-CFS research
NKX2-1 drives surfactant protein gene expression in alveolar type II cells; variants may affect lung regeneration capacity and alveolar repair in Long COVID pulmonary complications.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NKX2-1
rs6604946 is one of 1 known variant in the NKX2-1 gene. To understand the full biological context of this variant, explore the parent gene page.
View NKX2-1 gene page →Conditions studied in relation to rs6604946
Research into NKX2-1 variants including rs6604946 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NKX2-1 and the rs6604946 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs6604946 variant in the NKX2-1 gene?
rs6604946 is a single nucleotide polymorphism (SNP) located in the NKX2-1 (NK2 Homeobox 1 (TTF-1)) gene, which is involved in lung development / surfactant gene regulation. NKX2-1 encodes thyroid transcription factor 1 (TTF-1/NK2.1), the master regulator of lung development and surfactant gene expression in alveolar type II cells.
How may the rs6604946 variant relate to Long COVID or ME/CFS?
NKX2-1 drives surfactant protein gene expression in alveolar type II cells; variants may affect lung regeneration capacity and alveolar repair in Long COVID pulmonary complications.
Can a consumer DNA test detect the rs6604946 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs6604946 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NKX2-1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]American Journal of Respiratory Cell and Molecular Biology