rs8079034
Variant in the NLRP1 gene (NLR Family Pyrin Domain Containing 1)
rs8079034 is a single nucleotide polymorphism (SNP) in the NLRP1 gene, involved in inflammasome / innate immune sensing. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs8079034 variant?
rs8079034 is a SNP (single nucleotide polymorphism) in the NLRP1 (NLR Family Pyrin Domain Containing 1) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. NLRP1 forms an inflammasome activated by bacterial muramyl dipeptide and certain pathogens, triggering caspase-1 and pyroptosis.
Biological role and pathway
This variant sits within the NLRP1 gene, which is involved in the inflammasome / innate immune sensing pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs8079034 and Long COVID / ME-CFS research
NLRP1 polymorphisms are associated with autoimmune and inflammatory diseases; variants may affect inflammasome-driven inflammation and autoimmune features of Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NLRP1
rs8079034 is one of 2 known variants in the NLRP1 gene. To understand the full biological context of this variant, explore the parent gene page.
View NLRP1 gene page →Conditions studied in relation to rs8079034
Research into NLRP1 variants including rs8079034 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NLRP1 and the rs8079034 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the NLRP1 gene
The following variants in NLRP1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs8079034 variant in the NLRP1 gene?
rs8079034 is a single nucleotide polymorphism (SNP) located in the NLRP1 (NLR Family Pyrin Domain Containing 1) gene, which is involved in inflammasome / innate immune sensing. NLRP1 forms an inflammasome activated by bacterial muramyl dipeptide and certain pathogens, triggering caspase-1 and pyroptosis.
How may the rs8079034 variant relate to Long COVID or ME/CFS?
NLRP1 polymorphisms are associated with autoimmune and inflammatory diseases; variants may affect inflammasome-driven inflammation and autoimmune features of Long COVID.
Can a consumer DNA test detect the rs8079034 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs8079034 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NLRP1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33398161
- [2]Nature Genetics
- [3]Nature Immunology