rs756773

What is the rs756773 variant?

rs756773 is a SNP (single nucleotide polymorphism) in the NLRX1 (NLR Family Member X1) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. NLRX1 is a mitochondria-localized NLR protein that negatively regulates MAVS-mediated antiviral signaling and ROS production.

Biological role and pathway

This variant sits within the NLRX1 gene, which is involved in the innate immune regulation / mitochondrial antiviral pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: NLRX1

rs756773 is one of 1 known variant in the NLRX1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs756773

Research into NLRX1 variants including rs756773 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NLRX1 and the rs756773 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions